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Journal article

Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.

Abstract:

Many biological processes are regulated by protein-protein interactions (PPIs) and as such their misregulation can cause a multitude of diseases. Often the interactions between large proteins are mediated by small protein secondary structural domains, which project a minimum number of specifically arranged residues into the complementary surface of an interacting protein. Nature has the advantage of time, and over time has optimized those secondary structures, such as alpha-helices, beta-shee...

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Publication status:
Published

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Publisher copy:
10.1016/j.cbpa.2010.04.001

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Current opinion in chemical biology
Volume:
14
Issue:
3
Pages:
341-346
Publication date:
2010-06-01
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
Source identifiers:
117494
Language:
English
Keywords:
Pubs id:
pubs:117494
UUID:
uuid:387385b2-7815-401a-97b9-b4659637f658
Local pid:
pubs:117494
Deposit date:
2012-12-19

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