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Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.

Abstract:

Many biological processes are regulated by protein-protein interactions (PPIs) and as such their misregulation can cause a multitude of diseases. Often the interactions between large proteins are mediated by small protein secondary structural domains, which project a minimum number of specifically arranged residues into the complementary surface of an interacting protein. Nature has the advantage of time, and over time has optimized those secondary structures, such as alpha-helices, beta-shee...

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Publication status:
Published

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Publisher copy:
10.1016/j.cbpa.2010.04.001

Authors


Cummings, CG More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Current opinion in chemical biology
Volume:
14
Issue:
3
Pages:
341-346
Publication date:
2010-06-05
DOI:
EISSN:
1879-0402
ISSN:
1367-5931
URN:
uuid:387385b2-7815-401a-97b9-b4659637f658
Source identifiers:
117494
Local pid:
pubs:117494

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