- Abstract:
-
Many biological processes are regulated by protein-protein interactions (PPIs) and as such their misregulation can cause a multitude of diseases. Often the interactions between large proteins are mediated by small protein secondary structural domains, which project a minimum number of specifically arranged residues into the complementary surface of an interacting protein. Nature has the advantage of time, and over time has optimized those secondary structures, such as alpha-helices, beta-shee...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.cbpa.2010.04.001
-
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- Journal:
- Current opinion in chemical biology
- Volume:
- 14
- Issue:
- 3
- Pages:
- 341-346
- Publication date:
- 2010-06-05
- DOI:
- EISSN:
-
1879-0402
- ISSN:
-
1367-5931
- URN:
-
uuid:387385b2-7815-401a-97b9-b4659637f658
- Source identifiers:
-
117494
- Local pid:
- pubs:117494
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.
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