Journal article
Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics.
- Abstract:
-
Many biological processes are regulated by protein-protein interactions (PPIs) and as such their misregulation can cause a multitude of diseases. Often the interactions between large proteins are mediated by small protein secondary structural domains, which project a minimum number of specifically arranged residues into the complementary surface of an interacting protein. Nature has the advantage of time, and over time has optimized those secondary structures, such as alpha-helices, beta-shee...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.cbpa.2010.04.001
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Bibliographic Details
- Journal:
- Current opinion in chemical biology
- Volume:
- 14
- Issue:
- 3
- Pages:
- 341-346
- Publication date:
- 2010-06-01
- DOI:
- EISSN:
-
1879-0402
- ISSN:
-
1367-5931
- Source identifiers:
-
117494
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:117494
- UUID:
-
uuid:387385b2-7815-401a-97b9-b4659637f658
- Local pid:
- pubs:117494
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2010
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