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Thesis

Brain neurokinin-1 receptors in depression and interactions with the serotonin system

Abstract:

Emerging evidence suggests neurokinin-1 receptors (NK1Rs) may be altered in depression and NK1R antagonists may have antidepressant properties. In addition, blockade or deletion of NK1Rs has been shown to increase neuronal firing in the dorsal raphe nucleus suggestive of an interaction with the serotonin (5-HT) system. Against this background, one main aim of this thesis was to investigate anatomical interactions in the rat brain between NK1Rs and the 5-HT system. The second main aim was t...

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Division:
MSD
Department:
Pharmacology
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3872d6ea-090b-4cd7-840f-01681d8ae7e1
Deposit date:
2019-07-30

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