Journal article icon

Journal article

The level of insulin growth factor-1 receptor expression is directly correlated with the tumor uptake of (111)In-IGF-1(E3R) in vivo and the clonogenic survival of breast cancer cells exposed in vitro to trastuzumab (Herceptin).

Abstract:

INTRODUCTION: Our objective was to define the relationships between tumor uptake of [(111)In]-IGF-1 and [(111)In]-IGF-1(E3R), an analogue which does not bind insulin growth factor-1 (IGF-1) binding proteins (i.e., IGFBP-3), and the level of IGF-1 receptor (IGF-1R) expression on human breast cancer (BC) xenografts in athymic mice, as well as the feasibility for tumor imaging. A second objective was to correlate IGF-1R (and HER2 density) with the cytotoxicity of trastuzumab in the absence/pres...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
McLarty, K More by this author
Kersemans, V More by this author
Reilly, RM More by this author
Journal:
Nuclear medicine and biology
Volume:
35
Issue:
6
Pages:
645-653
Publication date:
2008-08-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:386e5d52-a2ee-4116-8af6-d86ce647926c
Source identifiers:
255914
Local pid:
pubs:255914

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP