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Journal article

ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex.

Abstract:

BACKGROUND: The Cohesin complex that holds sister chromatins together until anaphase is comprised of three core subunits: Smc1 and Smc3, two long-rod-shaped proteins with an ABC-like ATPase head (nucleotide-binding domain [NBD]) and a dimerization domain linked by a 50 nm long intramolecular antiparallel coiled-coil, and Scc1, an α-kleisin subunit interconnecting the NBD domains of Smc1 and Smc3. Cohesin's stable association with chromosomes is thought to involve entrapment of chromatin fiber...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2010.12.004

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Journal:
Current biology : CB
Volume:
21
Issue:
1
Pages:
12-24
Publication date:
2011-01-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:38658701-0f83-44e3-a0f4-c9cb08284727
Source identifiers:
110180
Local pid:
pubs:110180

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