BACKGROUND: The Cohesin complex that holds sister chromatins together until anaphase is comprised of three core subunits: Smc1 and Smc3, two long-rod-shaped proteins with an ABC-like ATPase head (nucleotide-binding domain [NBD]) and a dimerization domain linked by a 50 nm long intramolecular antiparallel coiled-coil, and Scc1, an α-kleisin subunit interconnecting the NBD domains of Smc1 and Smc3. Cohesin's stable association with chromosomes is thought to involve entrapment of chromatin fiber...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
ATP hydrolysis is required for relocating cohesin from sites occupied by its Scc2/4 loading complex.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record