Selective serotonin reuptake inhibitors versus tricyclic and heterocyclic antidepressants: comparison of drug adherence.

Journal article

BACKGROUND: Selective serotonin reuptake inhibitors are thought to have better discontinuation rates (i.e. less people dropping out) than tricyclic and heterocyclic antidepressant drugs. It is important to quantify the drop-out rates of different antidepressant drugs in order to have a better understanding of the relative tolerability of these drugs. OBJECTIVES: To assess the comparative tolerability of selective serotonin reuptake inhibitors and tricyclic/heterocyclic antidepressant drugs. ...

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Authors: Barbui, C; Hotopf, M; Freemantle, N; Boynton, J; Churchill, R

• Journal: Cochrane database of systematic reviews
• Issue: 4
• Pages: CD002791
• Publication date: 2000-01-01
• DOI: 10.1002/14651858.cd002791
• EISSN: 1469-493X
• Language: English
• Keywords: Depression; Patient Dropouts; Antidepressive Agents; Randomized Controlled Trials as Topic; Antidepressive Agents, Tricyclic; Serotonin Uptake Inhibitors; Humans