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Journal article

Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis.

Abstract:

MEN type 1 is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroids, anterior pituitary, and pancreatic islet cells. The MEN1 gene, which is located on chromosome 11q13, consists of 10 exons and encodes a 610-amino acid protein named MENIN. The observation of LOH involving 11q13 in MEN type 1 tumors and the inactivating germline mutations found in patients suggest that the MEN1 gene acts as a tumor suppressor, in keeping with the "two-hit" model...

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Publication status:
Published

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Publisher copy:
10.1210/jc.86.9.4371

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
Journal:
Journal of clinical endocrinology and metabolism
Volume:
86
Issue:
9
Pages:
4371-4374
Publication date:
2001-09-01
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
Source identifiers:
26943
Language:
English
Keywords:
Pubs id:
pubs:26943
UUID:
uuid:386194d0-f548-43e3-af6a-0a57fb64cca6
Local pid:
pubs:26943
Deposit date:
2012-12-19

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