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Journal article

Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis.

Abstract:

MEN type 1 is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroids, anterior pituitary, and pancreatic islet cells. The MEN1 gene, which is located on chromosome 11q13, consists of 10 exons and encodes a 610-amino acid protein named MENIN. The observation of LOH involving 11q13 in MEN type 1 tumors and the inactivating germline mutations found in patients suggest that the MEN1 gene acts as a tumor suppressor, in keeping with the "two-hit" model...

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Publication status:
Published

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Publisher copy:
10.1210/jc.86.9.4371

Authors


Pannett, AA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
The Journal of clinical endocrinology and metabolism
Volume:
86
Issue:
9
Pages:
4371-4374
Publication date:
2001-09-05
DOI:
EISSN:
1945-7197
ISSN:
0021-972X
URN:
uuid:386194d0-f548-43e3-af6a-0a57fb64cca6
Source identifiers:
26943
Local pid:
pubs:26943

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