Journal article
Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis.
- Abstract:
-
MEN type 1 is an autosomal dominant disorder characterized by the combined occurrence of tumors of the parathyroids, anterior pituitary, and pancreatic islet cells. The MEN1 gene, which is located on chromosome 11q13, consists of 10 exons and encodes a 610-amino acid protein named MENIN. The observation of LOH involving 11q13 in MEN type 1 tumors and the inactivating germline mutations found in patients suggest that the MEN1 gene acts as a tumor suppressor, in keeping with the "two-hit" model...
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- Publication status:
- Published
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- Publisher copy:
- 10.1210/jc.86.9.4371
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Bibliographic Details
- Journal:
- The Journal of clinical endocrinology and metabolism
- Volume:
- 86
- Issue:
- 9
- Pages:
- 4371-4374
- Publication date:
- 2001-09-05
- DOI:
- EISSN:
-
1945-7197
- ISSN:
-
0021-972X
- URN:
-
uuid:386194d0-f548-43e3-af6a-0a57fb64cca6
- Source identifiers:
-
26943
- Local pid:
- pubs:26943
Item Description
Terms of use
- Copyright date:
- 2001
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