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Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.

Abstract:

The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense r...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.7554/eLife.13044

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
MacGregor, P More by this author
Peacock, L More by this author
Macleod, OJ More by this author
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Funding agency for:
Lane-Serff, H
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Funding agency for:
Higgins, MK
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Funding agency for:
Carrington, M
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
5
Publication date:
2016-04-15
DOI:
EISSN:
2050-084X
URN:
uuid:385b8f89-6f58-4e02-9007-75ea6520af54
Source identifiers:
616799
Local pid:
pubs:616799

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