Journal article icon

Journal article

Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor.

Abstract:

The haptoglobin-haemoglobin receptor of the African trypanosome species, Trypanosoma brucei, is expressed when the parasite is in the bloodstream of the mammalian host, allowing it to acquire haem through the uptake of haptoglobin-haemoglobin complexes. Here we show that in Trypanosoma congolense this receptor is instead expressed in the epimastigote developmental stage that occurs in the tsetse fly, where it acts as a haemoglobin receptor. We also present the structure of the T. congolense r...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.7554/eLife.13044

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Higgins, M
Grant:
MR/L008246
More from this funder
Funding agency for:
Lane-Serff, H
Grant:
PhD program in Structural Biology
More from this funder
Funding agency for:
Carrington, M
Grant:
MR/L008246
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
5
Publication date:
2016-04-15
Acceptance date:
2016-04-14
DOI:
EISSN:
2050-084X
Source identifiers:
616799
Language:
English
Keywords:
Pubs id:
pubs:616799
UUID:
uuid:385b8f89-6f58-4e02-9007-75ea6520af54
Local pid:
pubs:616799
Deposit date:
2016-04-21

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP