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Biological consequences of radiation-induced DNA damage: relevance to radiotherapy.

Abstract:

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The pattern of the discrete energy depositions during passage of the ionising track of radiation defines the spatial distribution of lesions induced in DNA with a fraction of the DNA damage sites containing clusters of lesions, formed over a few nanometres, against a background of endogenously induced individual le...

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Publication status:
Published

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Publisher copy:
10.1016/j.clon.2013.06.007

Authors


Folkes, LK More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Clinical oncology (Royal College of Radiologists (Great Britain))
Volume:
25
Issue:
10
Pages:
578-585
Publication date:
2013-10-05
DOI:
EISSN:
1433-2981
ISSN:
0936-6555
URN:
uuid:385b35a4-f537-42d8-afe1-a56cfe232d6d
Source identifiers:
411668
Local pid:
pubs:411668
Language:
English
Keywords:

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