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Biological consequences of radiation-induced DNA damage: relevance to radiotherapy.

Abstract:

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The pattern of the discrete energy depositions during passage of the ionising track of radiation defines the spatial distribution of lesions induced in DNA with a fraction of the DNA damage sites containing clusters of lesions, formed over a few nanometres, against a background of endogenously induced individual le...

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Publication status:
Published

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Publisher copy:
10.1016/j.clon.2013.06.007

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Clinical oncology (Royal College of Radiologists (Great Britain))
Volume:
25
Issue:
10
Pages:
578-585
Publication date:
2013-10-01
DOI:
EISSN:
1433-2981
ISSN:
0936-6555
Source identifiers:
411668
Language:
English
Keywords:
Pubs id:
pubs:411668
UUID:
uuid:385b35a4-f537-42d8-afe1-a56cfe232d6d
Local pid:
pubs:411668
Deposit date:
2013-12-11

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