Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload.

Journal article

The response to strength training varies widely between individuals and is considerably influenced by genetic variables, which until now, have remained unidentified. The deletion (D), rather than the insertion (I), variant of the human angiotensin-converting enzyme (ACE) genotype is an important factor in the hypertrophic response of cardiac muscle to exercise and could also be involved in skeletal muscle hypertrophy - an important factor in the response to functional overload. Subjects were ...

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Authors: Folland, J; Leach, B; Little, T; Hawker, K; Myerson, S

• Publication status: Published
• Journal: Experimental physiology
• Volume: 85
• Issue: 5
• Pages: 575-579
• Publication date: 2000-09-01
• DOI: 10.1017/s0958067000020571
• EISSN: 1469-445X
• ISSN: 0958-0670
• Language: English
• Keywords: Muscle, Skeletal; Polymorphism, Genetic; Adult; Physical Fitness; Isometric Contraction; Polymerase Chain Reaction; Alleles; Exercise; Isoenzymes; Humans; Adolescent; Peptidyl-Dipeptidase A; Genotype; Weight-Bearing; Male; Hypertrophy