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Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys

Abstract:
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1038/s41591-018-0056-0

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Institution:
University of Oxford
Division:
Medical Sciences Division
Role:
Author
National Institute for Health Research Biomedical Research Centre Programme More from this funder
MRC-Newton UK More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Nature Medicine Journal website
Volume:
24
Pages:
721–723
Publication date:
2018-06-04
Acceptance date:
2018-03-29
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Pubs id:
pubs:842328
URN:
uri:3857fff5-d93a-4ffc-b0e0-deb5807b53e1
UUID:
uuid:3857fff5-d93a-4ffc-b0e0-deb5807b53e1
Local pid:
pubs:842328

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