- Abstract:
- Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted Manuscript
- Files:
-
-
(pdf, 67.8KB)
-
(pdf, 281.7KB)
-
- Publisher copy:
- 10.1038/s41591-018-0056-0
-
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- Publisher:
- Springer Nature Publisher's website
- Journal:
- Nature Medicine Journal website
- Volume:
- 24
- Pages:
- 721–723
- Publication date:
- 2018-06-04
- Acceptance date:
- 2018-03-29
- DOI:
- EISSN:
-
1546-170X
- ISSN:
-
1078-8956
- Pubs id:
-
pubs:842328
- URN:
-
uri:3857fff5-d93a-4ffc-b0e0-deb5807b53e1
- UUID:
-
uuid:3857fff5-d93a-4ffc-b0e0-deb5807b53e1
- Local pid:
- pubs:842328
- Copyright holder:
- Abbink et al.
- Copyright date:
- 2018
- Notes:
-
This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41591-018-0056-0
Journal article
Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys
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Funding
National Institute for Health Research Biomedical Research Centre Programme
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MRC-Newton UK
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