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A threshold concentration of anti-merozoite antibodies is required for protection from clinical episodes of malaria.

Abstract:

Antibodies to selected Plasmodium falciparum merozoite antigens are often reported to be associated with protection from malaria in one epidemiological cohort, but not in another. Here, we sought to understand this paradox by exploring the hypothesis that a threshold concentration of antibodies is necessary for protection. We analyzed data from two independent cohorts along the Kenyan coast, one in which antibodies to AMA1, MSP-2 and MSP-3 were associated with protection from malaria (Chonyi)...

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Publication status:
Published

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Authors


Murungi, LM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Theisen, M More by this author
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Journal:
Vaccine
Volume:
31
Issue:
37
Pages:
3936-3942
Publication date:
2013-08-05
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:384eac31-08a6-445d-9f2e-ebcb72915d47
Source identifiers:
407820
Local pid:
pubs:407820

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