Thesis
Mechanisms of genome regulation in human islets and their role in the pathogenesis of type 2 diabetes
- Abstract:
-
Genome-wide association studies (GWAS) have made substantial progress in implicating genomic regions in type 2 diabetes (T2D) susceptibility. Whilst attributing causal mechanisms to loci has proved non trivial, these studies have provided insights into the genetic architecture underlying the disease. GWAS findings indicate a causal role for gene regulatory processes, and suggest that pancreatic beta-cells play a pivotal role in mediating common T2D association. Work presented in this thesi...
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Authors
Contributors
+ McCarthy, M
Division:
MSD
Department:
NDM
Role:
Supervisor
+ Gloyn, A
Division:
MSD
Department:
NDM
Role:
Supervisor
Bibliographic Details
- Publication date:
- 2014
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:384baf0e-25b7-4ae4-a9c3-fee649d45368
- Local pid:
- ora:10078
- Deposit date:
- 2015-02-17
Terms of use
- Copyright holder:
- Gerrit Martinus van de Bunt
- Copyright date:
- 2014
- Notes:
- This thesis is not currently available in ORA.
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