A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines.

Journal article

Following the cessation of the global malaria eradication initiative in the 1970s, the prime objective of malarial intervention has been to reduce morbidity and mortality. This motivated the development of high throughput assays to determine the impact of interventions on asexual bloodstage parasites. In response to the new eradication agenda, interrupting parasite transmission from the human to the mosquito has been recognised as an important and additional target for intervention. Current a...

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Authors: Delves, M; Ramakrishnan, C; Blagborough, A; Leroy, D; Wells, T

• Journal: International journal for parasitology
• Volume: 42
• Issue: 11
• Pages: 999-1006
• Publication date: 2012-10-01
• DOI: 10.1016/j.ijpara.2012.08.009
• EISSN: 1879-0135
• ISSN: 0020-7519
• Language: English
• Keywords: Female; Luminescent Measurements; Germ Cells; Biological Assay; Antimalarials; Insect Vectors; Malaria Vaccines; Reproducibility of Results; Sensitivity and Specificity; Mice; Plasmodium malariae; Animals; Parasitic Sensitivity Tests; Plasmodium berghei