DNA base damage recognition and processing

Journal article

In living cells DNA base lesions are formed continuously as a consequence of normal metabolism and are also generated by a number of external factors. Simple base damages are repaired by base excision repair that is initiated by a damage specific DNA glycosylase, which removes the damaged base creating an abasic site (apurinic/apyrimidinic, AP site). AP endonuclease cleaves the phosphodiester bond 5′ to the AP site and then DNA polymerase β adds the first nucleotide to the 3′-end of the incis...

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Authors: Dianov, G; Allinson, S

• Journal: Genome Dynamics and Stability
• Volume: 1
• Pages: 287-314
• Publication date: 2007-01-01
• DOI: 10.1007/7050_007
• EISSN: 1861-3381
• ISSN: 1861-3373
• Language: English