Journal article
Quantifying antibiotic impact on within-patient dynamics of extended-spectrum beta-lactamase resistance
- Abstract:
-
Antibiotic-induced perturbation of the human gut flora is expected to play an important role in mediating the relationship between antibiotic use and the population prevalence of antibiotic resistance in bacteria, but little is known about how antibiotics affect within-host resistance dynamics. Here we develop a data-driven model of the within-host dynamics of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae. We use blaCTX-M (the most widespread ESBL gene family) and 16S r...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Department for International Development
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Bibliographic Details
- Publisher:
- eLife Sciences Publications Publisher's website
- Journal:
- eLife Journal website
- Volume:
- 9
- Article number:
- e49206
- Publication date:
- 2020-05-07
- Acceptance date:
- 2020-03-22
- DOI:
- EISSN:
-
2050-084X
- Pmid:
-
32379042
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
1103826
- Local pid:
- pubs:1103826
- Deposit date:
- 2020-08-13
Terms of use
- Copyright holder:
- Niehus et al.
- Copyright date:
- 2020
- Rights statement:
- © 2020 Niehus et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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