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Biphasic opening of the blood-brain barrier following transient focal ischemia: effects of hypothermia.

Abstract:

OBJECTIVE: Tracer constants (Ki) for blood-to-brain diffusion of sucrose were measured in the rat to profile the time course of blood-brain barrier injury after temporary focal ischemia, and to determine the influence of post-ischemic hypothermia. METHODS: Spontaneously hypertensive rats were subjected to transient (2 hours) clip occlusion of the right middle cerebral artery. Reperfusion times ranged from 1.5 min to 46 hours, and i.v. 3H-sucrose was circulated for 30 min prior to each time po...

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Publication status:
Published

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Authors


Preston, E More by this author
More by this author
Institution:
University of Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Volume:
26
Issue:
4
Pages:
298-304
Publication date:
1999-11-05
ISSN:
0317-1671
URN:
uuid:383d24a7-c992-4d0a-9b34-e6faeb8590c1
Source identifiers:
79118
Local pid:
pubs:79118

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