Journal article
Mechanism of action of 5-aminosalicylic acid and its derivatives.
- Abstract:
- The mechanism of action of 5-ASA and its derivatives remains obscure. The most likely mechanisms would appear to be an interrelationship between local production of eicosanoids and reactive oxygen metabolites, in conjunction with activated neutrophils, though the nature of the initial triggering factor/s remains to be determined. The possibility that bacterial-derived chemotactic peptides, such as FMLP, might be a triggering factor is an attractive possibility, made possible by an underlying defect in mucosal permeability.
- Publication status:
- Published
Actions
Authors
Bibliographic Details
- Journal:
- Clinical science (London, England : 1979)
- Volume:
- 78
- Issue:
- 2
- Pages:
- 119-125
- Publication date:
- 1990-02-01
- EISSN:
-
1470-8736
- ISSN:
-
0143-5221
- Source identifiers:
-
135322
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:135322
- UUID:
-
uuid:38340ad5-ab37-4868-bcb8-8d00c15af731
- Local pid:
- pubs:135322
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 1990
If you are the owner of this record, you can report an update to it here: Report update to this record