Mechanism of action of 5-aminosalicylic acid and its derivatives.

Ireland, A; Jewell, DP

Abstract:

The mechanism of action of 5-ASA and its derivatives remains obscure. The most likely mechanisms would appear to be an interrelationship between local production of eicosanoids and reactive oxygen metabolites, in conjunction with activated neutrophils, though the nature of the initial triggering factor/s remains to be determined. The possibility that bacterial-derived chemotactic peptides, such as FMLP, might be a triggering factor is an attractive possibility, made possible by an underlying defect in mucosal permeability.

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APA Style

Ireland, A., & Jewell, D. P. (1990). Mechanism of action of 5-aminosalicylic acid and its derivatives. Clinical Science (London, England : 1979), 78(2), 119–125.

MLA Style

Ireland, A., and D. P. Jewell. “Mechanism of Action of 5-Aminosalicylic Acid and Its Derivatives.” Clinical Science (London, England : 1979), vol. 78, no. 2, Clinical science (London, England : 1979), 1990, pp. 119–25.

Chicago Style

Ireland, A, and DP Jewell. 1990. “Mechanism of Action of 5-Aminosalicylic Acid and Its Derivatives.” Clinical Science (London, England : 1979) 78 (2): 119–25.
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Ireland, A More by this author

Jewell, DP More by this author

Bibliographic Details

Journal:: Clinical science (London, England : 1979)
Volume:: 78
Issue:: 2
Pages:: 119-125
Publication date:: 1990-02-05
EISSN:: 1470-8736
ISSN:: 0143-5221
URN:: uuid:38340ad5-ab37-4868-bcb8-8d00c15af731
Source identifiers:: 135322
Local pid:: pubs:135322

Item Description

Language:: English
Keywords:: Colon

Colitis, Ulcerative

Humans

Mesalamine

Aminosalicylic Acids

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License:: Terms and Conditions of Use for Oxford University Research Archive

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