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Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2.

Abstract:

Collagen type II-induced arthritis (CIA) is an experimental model of arthritis that has been successfully used to dissect the pathogenesis of human rheumatoid arthritis and to identify potential therapeutic targets. We have used this model to evaluate the role of T cell co-stimulation in both disease development and progression. T cell co-stimulation is provided by ligation of CD28 with either B7-1 or B7-2 present on antigen-presenting cells and can be prevented by a soluble form of CTLA-4 (C...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830261008

Authors


Walmsley, MJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
European journal of immunology
Volume:
26
Issue:
10
Pages:
2320-2328
Publication date:
1996-10-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:383179df-f8de-43af-9cd6-9791cddcbe80
Source identifiers:
481620
Local pid:
pubs:481620

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