- Abstract:
-
Early development of ionic models for cardiac myocytes, from the pioneering modification of the Hodgkin-Huxley giant squid axon model by Noble to the iconic DiFrancesco-Noble model integrating voltage-gated ionic currents, ion pumps and exchangers, Ca(2+) sequestration and Ca(2+)-induced Ca(2+) release, provided a general description for a mammalian Purkinje fibre (PF) and the framework for modern cardiac models. In the past two decades, development has focused on tissue-specific models with ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1098/rsta.2008.0283
-
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- Journal:
- Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
- Volume:
- 367
- Issue:
- 1896
- Pages:
- 2225-2255
- Publication date:
- 2009-06-05
- DOI:
- EISSN:
-
1471-2962
- ISSN:
-
1364-503X
- URN:
-
uuid:38227495-5377-496b-8699-ca38a1a9ccca
- Source identifiers:
-
239181
- Local pid:
- pubs:239181
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Mathematical models of the electrical action potential of Purkinje fibre cells.
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