Mathematical models of the electrical action potential of Purkinje fibre cells.
Early development of ionic models for cardiac myocytes, from the pioneering modification of the Hodgkin-Huxley giant squid axon model by Noble to the iconic DiFrancesco-Noble model integrating voltage-gated ionic currents, ion pumps and exchangers, Ca(2+) sequestration and Ca(2+)-induced Ca(2+) release, provided a general description for a mammalian Purkinje fibre (PF) and the framework for modern cardiac models. In the past two decades, development has focused on tissue-specific models with ...Expand abstract
- Publication status:
- Publisher copy:
- Philosophical transactions. Series A, Mathematical, physical, and engineering sciences
- Publication date:
- Source identifiers:
- Copyright date: