- Abstract:
-
Objective: FBXW7 encodes the substrate recognition component of a ubiquitin ligase that degrades targets such as Notch1, c-Jun, c-Myc and cyclin E. FBXW7 mutations occur in several tumour types, including colorectal cancers. The FBXW7 mutation spectrum in cancers is unusual. Some tumours have biallelic loss of function mutations but most have monoallelic missense mutations involving specific arginine residues at β-propellor tips involved in substrate recognition. Design: FBXW7 functional stud...
Expand abstract - Publisher copy:
- 10.1136/gutjnl-2013-304719
-
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- Publisher:
- BMJ Publishing Group
- Journal:
- Gut
- Volume:
- 63
- Issue:
- 5
- Pages:
- 792-799
- Publication date:
- 2014-05-01
- DOI:
- EISSN:
-
1468-3288
- ISSN:
-
0017-5749
- URN:
-
uuid:381b628e-22d0-4045-b20a-e2aa3dc0e9ac
- Source identifiers:
-
464179
- Local pid:
- pubs:464179
- Language:
- English
- Copyright date:
- 2014
Journal article
Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines
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