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Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

Abstract:

Objective: FBXW7 encodes the substrate recognition component of a ubiquitin ligase that degrades targets such as Notch1, c-Jun, c-Myc and cyclin E. FBXW7 mutations occur in several tumour types, including colorectal cancers. The FBXW7 mutation spectrum in cancers is unusual. Some tumours have biallelic loss of function mutations but most have monoallelic missense mutations involving specific arginine residues at β-propellor tips involved in substrate recognition. Design: FBXW7 functional stud...

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Publisher copy:
10.1136/gutjnl-2013-304719

Authors


Behrens, A More by this author
Tomlinson, I More by this author
Publisher:
BMJ Publishing Group
Journal:
Gut
Volume:
63
Issue:
5
Pages:
792-799
Publication date:
2014-05-01
DOI:
EISSN:
1468-3288
ISSN:
0017-5749
URN:
uuid:381b628e-22d0-4045-b20a-e2aa3dc0e9ac
Source identifiers:
464179
Local pid:
pubs:464179
Language:
English

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