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Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection.

Abstract:

The CD8+ T cell response to Epstein-Barr virus (EBV) is well characterized. Much less is known about the evolution of the CD4+ T cell response. Here we show that EBV stimulates a primary burst of effector CD4+ T cells and this is followed by a period of down-regulation. A small population of EBV-specific effector CD4+ T cells survives during the lifelong persistent phase of infection. The EBV-specific effector CD4+ T cells accumulate within a CD27+ CD28+ differentiation compartment during pri...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20022058

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Journal:
The Journal of experimental medicine
Volume:
198
Issue:
6
Pages:
903-911
Publication date:
2003-09-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3804ffb5-3359-4afb-9e17-a78cffc1bf3c
Source identifiers:
32457
Local pid:
pubs:32457

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