Copy number, linkage disequilibrium and disease association in the FCGR locus.

Journal article

The response of a leukocyte to immune complexes (ICs) is modulated by receptors for the Fc region of IgG (FcgammaRs), and alterations in their affinity or function have been associated with risk of autoimmune diseases, including systemic lupus erythematosus (SLE). The low-affinity FcgammaR genomic locus is complex, containing regions of copy number variation (CNV) which can alter receptor expression and leukocyte responses to IgG. Combined paralogue ratio tests (PRTs) were used to distinguish...

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Authors: Niederer, H; Willcocks, L; Rayner, T; Yang, W; Lau, Y

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 19
• Issue: 16
• Pages: 3282-3294
• Publication date: 2010-08-01
• DOI: 10.1093/hmg/ddq216
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Genotype; Sweden; European Continental Ancestry Group; Alleles; Asian Continental Ancestry Group; Gene Frequency; China; Gene Dosage; African Continental Ancestry Group; Kenya; Lupus Erythematosus, Systemic; Linkage Disequilibrium; Great Britain; Receptors, IgG; Polymorphism, Single Nucleotide; Genetic Predisposition to Disease; GPI-Linked Proteins; Chi-Square Distribution; Vietnam; Humans