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Journal article

[11C]-WAY100635 PET demonstrates marked 5-HT1A receptor changes in sporadic ALS.

Abstract:

The pathogenesis of amyotrophic lateral sclerosis (ALS) remains obscure, but it is now clear that neuronal loss is not confined to the motor cortex, even in cases without dementia. A reliable method of assessing cortical involvement in vivo remains elusive. WAY100635 binds selectively to the 5-hydroxytryptamine (5-HT1A) receptor, which is expressed on pyramidal neurones present throughout the cortex. [11C]-WAY100635 PET is, therefore, a potential marker of cerebral neuronal loss or dysfunctio...

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Publication status:
Published

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Publisher copy:
10.1093/brain/awh428

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Journal:
Brain : a journal of neurology
Volume:
128
Issue:
Pt 4
Pages:
896-905
Publication date:
2005-04-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:37f99a24-347c-46a3-9234-42ffe91d0bd6
Source identifiers:
373953
Local pid:
pubs:373953

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