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Journal article

Harnessing local and systemic immunity for vaccines against tuberculosis.

Abstract:

The lung is the portal of entry for Mycobacterium tuberculosis (Mtb) and animal experimental evidence indicates that local immune defense mechanisms are crucial for protective immunity. Immunization via the lower respiratory tract efficiently induces a dividing, activated, antigen-dependent, lung-resident, memory T-cell population, which is partly recoverable by bronchoalveolar lavage. These cells can inhibit the growth of Mtb in the lungs immediately after infection. Delivery of appropriate ...

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Publication status:
Published

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Publisher copy:
10.1038/mi.2013.99

Authors


Journal:
Mucosal immunology
Volume:
7
Issue:
1
Pages:
20-26
Publication date:
2014-01-05
DOI:
EISSN:
1935-3456
ISSN:
1933-0219
URN:
uuid:37ecd4ec-2354-49ed-b654-6ff7c5423a0b
Source identifiers:
440313
Local pid:
pubs:440313

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