The lung is the portal of entry for Mycobacterium tuberculosis (Mtb) and animal experimental evidence indicates that local immune defense mechanisms are crucial for protective immunity. Immunization via the lower respiratory tract efficiently induces a dividing, activated, antigen-dependent, lung-resident, memory T-cell population, which is partly recoverable by bronchoalveolar lavage. These cells can inhibit the growth of Mtb in the lungs immediately after infection. Delivery of appropriate ...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Harnessing local and systemic immunity for vaccines against tuberculosis.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record