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Novel, chimpanzee serotype 68-based adenoviral vaccine carrier for induction of antibodies to a transgene product.

Abstract:

An E1-deletion-containing adenoviral recombinant based on the chimpanzee serotype 68 (AdC68) was developed to express the rabies virus glycoprotein. Mice immunized with this construct (AdC68rab.gp) developed antibodies to rabies virus and remained resistant to challenge with an otherwise lethal dose of rabies virus. In naïve mice immunized intranasally, the rabies virus-specific antibody responses elicited by AdC68rab.gp were comparable with regard to both titers and isotype profiles to those...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Role:
Author
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Journal:
Journal of virology
Volume:
76
Issue:
6
Pages:
2667-2675
Publication date:
2002-03-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:37ebe3a5-c0b4-4914-8593-7891f4315c46
Source identifiers:
230995
Local pid:
pubs:230995

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