- Abstract:
-
Erythropoietin, the major hormone controlling red-cell production, is regulated in part through oxygen-dependent changes in the rate of transcription of its gene. Using transient transfection in HepG2 cells, we have defined a DNA sequence, located 120 base pairs 3' to the poly(A)-addition site of the mouse erythropoietin gene, that confers oxygen-regulated expression on a variety of heterologous promoters. The sequence has the typical features of a eukaryotic enhancer. Approximately 70 base p...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.88.23.10553
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 88
- Issue:
- 23
- Pages:
- 10553-10557
- Publication date:
- 1991-12-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:37e95d29-5d58-4daf-bc9b-163a64d94b14
- Source identifiers:
-
16626
- Local pid:
- pubs:16626
- Language:
- English
- Keywords:
- Copyright date:
- 1991
Journal article
Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.
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