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Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

Abstract:

Erythropoietin, the major hormone controlling red-cell production, is regulated in part through oxygen-dependent changes in the rate of transcription of its gene. Using transient transfection in HepG2 cells, we have defined a DNA sequence, located 120 base pairs 3' to the poly(A)-addition site of the mouse erythropoietin gene, that confers oxygen-regulated expression on a variety of heterologous promoters. The sequence has the typical features of a eukaryotic enhancer. Approximately 70 base p...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.88.23.10553

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
88
Issue:
23
Pages:
10553-10557
Publication date:
1991-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:37e95d29-5d58-4daf-bc9b-163a64d94b14
Source identifiers:
16626
Local pid:
pubs:16626

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