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COX-2 inhibitors and the heart: are all coxibs the same?

Abstract:

The selective COX-2 inhibitors (coxibs) were originally developed to minimise the adverse effects of conventional non-steroidal anti-inflammatory drugs (NSAIDs) while maintaining the same analgesic and anti-inflammatory properties. Many large studies confirmed the improved gastric side effect profile of coxibs compared with non-selective NSAIDs; however, reports of increased cardiovascular morbidity and mortality followed, and the manufacturer Merck was forced to withdraw rofecoxib (Vioxx) fr...

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Publisher copy:
10.1136/pgmj.2005.042234

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Postgraduate medical journal
Volume:
82
Issue:
966
Pages:
242-245
Publication date:
2006-04-01
DOI:
EISSN:
1469-0756
ISSN:
0032-5473
Source identifiers:
414606
Language:
English
Keywords:
Pubs id:
pubs:414606
UUID:
uuid:37dcfc54-4a03-4598-a81f-67ce1a7c2c8d
Local pid:
pubs:414606
Deposit date:
2013-11-16

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