Role of the systemic immune system in brain metastasis.

Journal article

Metastatic disease in the central nervous system (CNS) is a cause of increasing mortality amongst cancer patients. As with other types of cancer, cells of the systemic immune system play a range of important roles in the development of metastatic lesions in the CNS, both repressing and promoting tumour growth. Recent advances in immunotherapy have changed the emphasis in cancer treatment away from conventional chemotherapy and radiotherapy for certain tumour types. Despite this, our understan...

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Authors: Hamilton, A; Sibson, N

• Publication status: Published
• Journal: Molecular and cellular neurosciences
• Volume: 53
• Pages: 42-51
• Publication date: 2013-03-01
• DOI: 10.1016/j.mcn.2012.10.004
• EISSN: 1095-9327
• ISSN: 1044-7431
• Language: English
• Keywords: Lymphocytes; Macrophages; Dendritic Cells; Humans; Blood-Brain Barrier; Blood Platelets; Killer Cells, Natural; Brain Neoplasms; Neutrophils; Inflammation