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Induction of organ dysfunction and up-regulation of inflammatory markers in the liver and kidneys of hypotensive brain dead rats: a model to study marginal organ donors.

Abstract:

BACKGROUND: Marginal donors exposed to the full array of effects induced by brain death are characterized by low success rates after transplantation. This study examined whether organs from marginal brain dead animals show any change in organ function or tissue activation making them eventually more susceptible for additional damage during preservation and transplantation. METHODS: To study this hypothesis we first focused on effects of brain death on donor organ quality by using a brain deat...

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Publication status:
Published

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Authors


van der Hoeven, JA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Surgical Sciences
Postema, F More by this author
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Volume:
68
Issue:
12
Pages:
1884-1890
Publication date:
1999-12-05
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
URN:
uuid:37d8c44c-bb9a-4af0-b2fe-07eb5a1fdc5c
Source identifiers:
191000
Local pid:
pubs:191000

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