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Biological implications of a discrete mathematical model for collagen deposition and alignment in dermal wound repair

Abstract:

We deveiop a novel mathematical model for collagen deposition and alignment during dermal wound healing. We focus on the interactions between fibroblasts, modelled as discrete entities, and a continuous extracellular matrix composed of collagen and a fibrin based blood clot. There are four basic interactions assumed in the model: fibroblasts orient the collagen matrix, fibroblasts produce and degrade collagen and fibrin and the matrix directs the fibroblasts and determines the speed of the ce...

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Publication date:
2000-01-01
UUID:
uuid:37c9d4bc-201e-4136-ba4f-3b0199d17562
Local pid:
oai:eprints.maths.ox.ac.uk:411
Deposit date:
2011-05-19

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