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Effect of injections of 6-OHDA into either nucleus accumbens septi or frontal cortex on spontaneous and drug-induced activity.

Abstract:

The effect of injections of 6-hydroxydopamine (6-OHDA) into either frontal cortex (FCx) or nucleus accumbens (NAS) on spontaneous, amphetamine and apomorphine photocell cage activity was studied. Both lesions groups had significant noradrenaline depletion in frontal cortex but only the FCx group had significant dopamine depletion in frontal cortex. Whereas NAS 6-OHDA rats exhibited enhanced apomorphine- and decreased amphetamine-activity there were no differences in activity of the FCx group....

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Neuropharmacology
Volume:
22
Issue:
9
Pages:
1141-1145
Publication date:
1983-09-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:37c53879-5010-47da-8cc7-02466c5bf30b
Source identifiers:
28777
Local pid:
pubs:28777

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