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Increased immunoreactivity of cdk5 activators in hippocampal sclerosis.

Abstract:

Cyclin-dependent kinase 5 is important in several in-vitro neurodegeneration paradigms. Whether cyclin-dependent kinase 5 contributes to cell death in human neurodegenerative diseases remains uncertain, particularly because post-mortem delay and other extrinsic factors might influence cyclin-dependent kinase 5 activity. Here we demonstrate increased immunoreactivity for the activators of cyclin-dependent kinase 5 in post-mortem human hippocampi affected by the neurodegenerative condition hipp...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Martinian, L More by this author
Yogarajah, M More by this author
Nikolic, M More by this author
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Journal:
Neuroreport
Volume:
18
Issue:
5
Pages:
511-516
Publication date:
2007-03-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:37b7531a-36dd-4446-906d-17bd9e36413a
Source identifiers:
461730
Local pid:
pubs:461730

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