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Individual Timp deficiencies differentially impact pro-MMP-2 activation.

Abstract:

Membrane-type matrix metalloproteinases (MT-MMPs) have emerged as key enzymes in tumor cell biology. The importance of MT1-MMP, in particular, is highlighted by its ability to activate pro-MMP-2 at the cell surface through the formation of a trimolecular complex comprised of MT1-MMP/tissue inhibitor of metalloproteinase-2 (TIMP-2)/pro-MMP-2. TIMPs 1-4 are physiological MMP inhibitors with distinct roles in the regulation of pro-MMP-2 processing. Here, we have shown that individual Timp defici...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m512009200

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Journal:
The Journal of biological chemistry
Volume:
281
Issue:
15
Pages:
10337-10346
Publication date:
2006-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:37ae85cf-94b2-4733-aa65-1c2d5c224877
Source identifiers:
226645
Local pid:
pubs:226645

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