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Journal article : Review

Altered immune cell differentiation in the lungs of patients with critical COVID-19

Abstract:

This preprint from Wauters et al. analysed the single-cell transcriptome of bronchoalveolar lavages from 5 patients with mild and 26 patients with critical COVID-19, and detected important differences in immune cell functionality. In mild COVID-19, T cells assumed a resident memory CD8+ or T helper 17 (TH17) cell phenotype, whereas in critical COVID-19 they acquired an exhausted phenotype. In mild COVID-19, monocytes differentiated into macrophages with phagocytic and antigen-presenting capac...

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Publication status:
Published
Peer review status:
Reviewed (other)

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Publisher copy:
10.1038/s41577-020-00438-2

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Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Publisher:
Nature Research Publisher's website
Journal:
Nature Reviews Immunology Journal website
Volume:
20
Issue:
10
Article number:
592
Publication date:
2020-08-21
Acceptance date:
2020-08-19
DOI:
EISSN:
1474-1741
ISSN:
1474-1733
Language:
English
Keywords:
Subtype:
Review
Pubs id:
1128322
Local pid:
pubs:1128322
Deposit date:
2020-08-25

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