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Journal article

Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cells.

Abstract:

Nicotinic acid adenine dinucleotide phosphate (NAADP) and cyclic adenosine diphosphate ribose (cADPR) were first demonstrated to mobilize Ca2+ in sea urchin eggs. In the absence of direct measurements of these messengers, pharmacological studies alone have implicated these molecules as intracellular second messengers for specific cell surface receptor agonists. We now report that in mouse pancreatic acinar cells, cholecystokinin, but not acetylcholine, evokes rapid and transient increases in ...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2005.04.033

Authors


Yamasaki, M More by this author
Thomas, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Garnham, C More by this author
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Journal:
Current biology : CB
Volume:
15
Issue:
9
Pages:
874-878
Publication date:
2005-05-05
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
URN:
uuid:3792725b-181c-4e33-9b81-e99c417f29e2
Source identifiers:
106319
Local pid:
pubs:106319

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