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The role of RNA processing in the pathogenesis of motor neuron degeneration.

Abstract:

Motor neurons are large, highly polarised cells with very long axons and a requirement for precise spatial and temporal gene expression. Neurodegenerative disorders characterised by selective motor neuron vulnerability include various forms of amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). A rapid expansion in knowledge on the pathophysiology of motor neuron degeneration has occurred in recent years, largely through the identification of genes leading to familial forms...

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Publication status:
Published

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Publisher copy:
10.1017/s1462399410001523

Authors


Bäumer, D More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Almeida, M More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Expert reviews in molecular medicine
Volume:
12
Pages:
e21
Publication date:
2010
DOI:
EISSN:
1462-3994
ISSN:
1462-3994
URN:
uuid:378dd133-66a1-4e98-89c5-9cedfc8a7e96
Source identifiers:
241981
Local pid:
pubs:241981

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