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Altered balance of excitatory and inhibitory learning in a genetically modified mouse model of glutamatergic dysfunction relevant to schizophrenia

Abstract:

The GluA1 AMPAR (encoded by the Gria1 gene) subunit has been implicated in schizophrenia. Gria1 knockout in mice results in recently experienced stimuli acquiring aberrantly high salience. This suggests that GluA1 may be important for learning that is sensitive to the temporal contiguity between events. To test this, mice were trained on a Pavlovian trace conditioning procedure in which the presentation of an auditory cue and food were separated by a temporal interval. Wild-type mice initiall...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-01925-8

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Department:
Oxford, MSD, Experimental Psychology
Role:
Author
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Department:
Oxford, MSD, Psychiatry
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Author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Pages:
Article: 1765
Publication date:
2017-05-11
Acceptance date:
2017-03-31
DOI:
ISSN:
2045-2322
Pubs id:
pubs:692194
URN:
uri:37868f01-5738-4da9-bbd7-962c5029e7ed
UUID:
uuid:37868f01-5738-4da9-bbd7-962c5029e7ed
Local pid:
pubs:692194

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