Conference item
Tumour suppression by a protein hydroxylase
- Abstract:
- ydroxylation is an emerging modification catalysed by a family of ‘2-oxoglutarate (2OG)-dependent oxygenases’ that includes the Collagen and HIF hydroxylases, TET 5hmC demethylases, and JmjC histone demethylases. These enzymes are widely implicated in cancer due to roles in hypoxia signalling, extracellular matrix formation, and epigenetics, and because of their inhibition by oncometabolites. Although other sub-families of 2OG-oxygenases exist they are less well characterised and their role in cancer remains largely unexplored.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 182.8KB)
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- Publisher copy:
- 10.1016/S0959-8049(16)61319-9
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Authors
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- 24th Biennial Congress of the European Association for Cancer Research (EACR24) Journal website
- Host title:
- 24th Biennial Congress of the European Association for Cancer Research (EACR24)
- Publication date:
- 2016-07-01
- DOI:
- ISSN:
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1879-0852 and 0959-8049
- Source identifiers:
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855861
Item Description
- Pubs id:
-
pubs:855861
- UUID:
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uuid:3785daf5-4509-44e0-8a2e-a7c826afdddc
- Local pid:
- pubs:855861
- Deposit date:
- 2018-06-06
Terms of use
- Copyright holder:
- Elsevier
- Copyright date:
- 2016
- Notes:
- © 2016 Elsevier Ltd. Published by Elsevier Inc. All rights reserved. This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/S0959-8049(16)61319-9
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