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Tumour suppression by a protein hydroxylase

Abstract:
ydroxylation is an emerging modification catalysed by a family of ‘2-oxoglutarate (2OG)-dependent oxygenases’ that includes the Collagen and HIF hydroxylases, TET 5hmC demethylases, and JmjC histone demethylases. These enzymes are widely implicated in cancer due to roles in hypoxia signalling, extracellular matrix formation, and epigenetics, and because of their inhibition by oncometabolites. Although other sub-families of 2OG-oxygenases exist they are less well characterised and their role in cancer remains largely unexplored.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S0959-8049(16)61319-9

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Ludwig Institute
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
24th Biennial Congress of the European Association for Cancer Research (EACR24) Journal website
Host title:
24th Biennial Congress of the European Association for Cancer Research (EACR24)
Publication date:
2016-07-01
DOI:
ISSN:
1879-0852 and 0959-8049
Source identifiers:
855861
Pubs id:
pubs:855861
UUID:
uuid:3785daf5-4509-44e0-8a2e-a7c826afdddc
Local pid:
pubs:855861
Deposit date:
2018-06-06

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