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Deacetylation inhibition reverses PABPN1-dependent muscle wasting

Abstract:

Reduced poly(A)-binding protein nuclear 1 (PABPN1) levels cause aging-associated muscle wasting. PABPN1 is a multifunctional regulator of mRNA processing. To elucidate the molecular mechanisms causing PABPN1-mediated muscle wasting, we compared the transcriptome with the proteome in mouse muscles expressing short hairpin RNA to PABPN1 (shPab). We found greater variations in the proteome than in mRNA expression profiles. Protein accumulation in the shPab proteome was concomitant with reduced p...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.isci.2019.01.024

Authors


Konietzny, R More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Target Discovery Institute
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Publisher:
Elsevier Publisher's website
Journal:
iScience Journal website
Volume:
12
Pages:
318-332
Publication date:
2019-01-22
Acceptance date:
2019-01-15
DOI:
EISSN:
2589-0042
ISSN:
2589-0042
Pubs id:
pubs:966936
URN:
uri:377db5f1-abd1-45ce-91d1-dfc83db3b888
UUID:
uuid:377db5f1-abd1-45ce-91d1-dfc83db3b888
Local pid:
pubs:966936
Language:
English

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