Journal article icon

Journal article

Assembly and transport mechanism of tripartite drug efflux systems.

Abstract:

Multidrug efflux (MDR) pumps remove a variety of compounds from the cell into the external environment. There are five different classes of MDR pumps in bacteria, and quite often a single bacterial species expresses multiple classes of pumps. Although under normal circumstances MDR pumps confer low-level intrinsic resistance to drugs, the presence of drugs and mutations in regulatory genes lead to high level expression of MDR pumps that can pose problems with therapeutic treatments. This revi...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Physics
Role:
Author
Journal:
Biochimica et biophysica acta
Volume:
1794
Issue:
5
Pages:
817-825
Publication date:
2009-05-05
DOI:
ISSN:
0006-3002
URN:
uuid:377c1526-1d6c-45fd-979a-55911cfa0b63
Source identifiers:
155946
Local pid:
pubs:155946

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP