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Genetic analysis of complex traits in the emerging Collaborative Cross

Abstract:

The Collaborative Cross (CC) is a mouse recombinant inbred strain panel that is being developed as a resource for mammalian systems genetics. Here we describe an experiment that uses partially inbred CC lines to evaluate the genetic properties and utility of this emerging resource. Genome-wide analysis of the incipient strains reveals high genetic diversity, balanced allele frequencies, and dense, evenly distributed recombination sites - all ideal qualities for a systems genetics resource. We...

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Publisher copy:
10.1101/gr.111310.110

Authors


Foulds-Mathes, W More by this author
Verdugo, RA More by this author
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Journal:
Genome Research
Volume:
21
Issue:
8
Pages:
1213-1222
Publication date:
2011-08-05
DOI:
EISSN:
1549-5469
ISSN:
1088-9051
URN:
uuid:377a26a1-b225-45ca-b935-8e375ec3032a
Source identifiers:
179210
Local pid:
pubs:179210
Language:
English

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