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Skin dendritic cell and T cell activation associated with dengue shock syndrome

Abstract:

The pathogenesis of severe dengue remains unclear, particularly the mechanisms underlying the plasma leakage that results in hypovolaemic shock in a small proportion of individuals. Maximal leakage occurs several days after peak viraemia implicating immunological pathways. Skin is a highly vascular organ and also an important site of immune reactions with a high density of dendritic cells (DCs), macrophages and T cells. We obtained skin biopsies and contemporaneous blood samples from patients...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41598-017-14640-1

Authors


Duyen, HTL More by this author
Velumani, S More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
Article: 14224
Publication date:
2017-10-27
DOI:
ISSN:
2045-2322
Pubs id:
pubs:742227
URN:
uri:37790689-ddce-404f-8c4b-6d3ee51e50b9
UUID:
uuid:37790689-ddce-404f-8c4b-6d3ee51e50b9
Local pid:
pubs:742227
Language:
English

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