T-cell responses in children to internal influenza antigens, 1 year after immunization with pandemic H1N1 influenza vaccine, and response to revaccination with seasonal trivalent-inactivated influenza vaccine.

Journal article

BACKGROUND: During seasonal influenza epidemics, 5-15% of the population are affected with an illness having a nontrivial mortality, morbidity and economic burden. Inactivated influenza vaccines are routinely used to prevent influenza infection, primarily by inducing humoral immunity. In addition, trivalent-inactivated influenza vaccines have previously been shown to boost influenza-specific T-cell responses in a small percentage of adults. We investigate here the influenza-specific T-cell re...

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Authors: Lambe, T; Spencer, A; Mullarkey, C; Antrobus, R; Yu, L

• Publication status: Published
• Journal: Pediatric infectious disease journal
• Volume: 31
• Issue: 6
• Pages: e86-e91
• Publication date: 2012-06-01
• DOI: 10.1097/inf.0b013e318255e443
• EISSN: 1532-0987
• ISSN: 0891-3668
• Language: English
• Keywords: Child, Preschool; Vaccines, Inactivated; Cells, Cultured; Influenza A Virus, H1N1 Subtype; Humans; Influenza Vaccines; Interferon-gamma; Influenza, Human; Immunization, Secondary; Leukocytes, Mononuclear; Antigens, Viral; Female; Male; Child; Infant