The UTX gene escapes X inactivation in mice and humans.

Journal article

We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Uty , which encodes a tetratricopeptide repeat (TPR) protein. A peptide derived from the UTY protein confers H-Y antigenicity on male cells. Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11.2. Given that Uty is ubiquitously transcribed, we assayed for ...

Expand abstract

Authors: Greenfield, A; Carrel, L; Pennisi, D; Philippe, C; Quaderi, N

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 7
• Issue: 4
• Pages: 737-742
• Publication date: 1998-04-01
• DOI: 10.1093/hmg/7.4.737
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Female; Humans; Polymerase Chain Reaction; Amino Acid Sequence; Blotting, Southern; Dosage Compensation, Genetic; Blotting, Northern; Transcription, Genetic; Mice; Male; Animals; Nuclear Proteins; Molecular Sequence Data; Proteins