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Prostate cancer meta-analysis of more than 140,000 men identifies 63 novel prostate cancer susceptibility loci

Abstract:

Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10−8) with PrCa and one locus significantly associated with early-on...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Files:
Publisher copy:
10.1038/s41588-018-0142-8

Authors


Schumacher, FR More by this author
Olama, AAA More by this author
Berndt, SI More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Surgical Sciences
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
50
Pages:
928–936
Publication date:
2018-06-11
Acceptance date:
2018-04-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pubs id:
pubs:800925
URN:
uri:376b5ec0-7754-4e1b-ace8-9da421cd15fa
UUID:
uuid:376b5ec0-7754-4e1b-ace8-9da421cd15fa
Local pid:
pubs:800925

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