Journal article icon

Journal article

Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells

Abstract:

The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cells remains unclear. Here, we purify and characterise LGP2/RNA complexes from cells infected with encephalomyocarditis virus (EMCV), a picornavirus detected by MDA5 and LGP2 but not RIG-I. We show that those complexes contain RNA that is highly enriched for MDA5-stimulatory activity and for a spec...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.7554/elife.01535

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
Expand authors...
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
2014
Issue:
3
Article number:
e01535
Publication date:
2014-02-18
Acceptance date:
2014-01-07
DOI:
EISSN:
2050-084X
Source identifiers:
449369
Language:
English
Keywords:
UUID:
uuid:37650747-7c97-4832-ab47-3398e21e57df
Local pid:
pubs:449369
Deposit date:
2014-07-16

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP