An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions.

Anichini, A; Molla, A; Mortarini, R; Tragni, G; Bersani, I; Di Nicola, M; Gianni, A; Pilotti, S; Dunbar, R; Cerundolo, V; Parmiani, G

Journal article

An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions.

Abstract:: It is not known if immune response to T cell-defined human histocompatibility leukocyte antigen (HLA) class I-restricted melanoma antigens leads to an expanded peripheral pool of T cells in all patients, affects cytotoxic T lymphocyte (CTL) generation, and correlates with anti-tumor response in metastatic lesions. To this end, a limiting dilution analysis technique was developed that allowed us to evaluate the same frequency of peptide-specific T cells as by staining T cells with HLA-peptide ...
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Publication status:: Published

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APA Style

Anichini, A., Molla, A., Mortarini, R., Tragni, G., Bersani, I., Di Nicola, M., Gianni, A., Pilotti, S., Dunbar, R., Cerundolo, V., & Parmiani, G. (1999). An expanded peripheral T cell population to a cytotoxic T lymphocyte (CTL)-defined, melanocyte-specific antigen in metastatic melanoma patients impacts on generation of peptide-specific CTLs but does not overcome tumor escape from immune surveillance in metastatic lesions. Journal of Experimental Medicine, 190(5), 651–667.

MLA Style

Anichini, A., et al. “An Expanded Peripheral T Cell Population to a Cytotoxic T Lymphocyte (CTL)-Defined, Melanocyte-Specific Antigen in Metastatic Melanoma Patients Impacts on Generation of Peptide-Specific CTLs but Does Not Overcome Tumor Escape from Immune Surveillance in Metastatic Lesions.” Journal of Experimental Medicine, vol. 190, no. 5, 1999, pp. 651–67.

Chicago Style

Anichini, A, A Molla, R Mortarini, G Tragni, I Bersani, M Di Nicola, A Gianni, et al. 1999. “An Expanded Peripheral T Cell Population to a Cytotoxic T Lymphocyte (CTL)-Defined, Melanocyte-Specific Antigen in Metastatic Melanoma Patients Impacts on Generation of Peptide-Specific CTLs but Does Not Overcome Tumor Escape from Immune Surveillance in Metastatic Lesions.” Journal of Experimental Medicine 190 (5): 651–67.
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