Journal article
Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults
- Abstract:
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Uncoupling protein 2 (UCP2) is a mitochondrial membrane protein that plays a role in uncoupling electron transport from adenosine triphosphate (ATP) formation. Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. Since UCP2 is expressed in several brain regions, we investigated in this study whether UCP2 polymorphisms might 1) affect occurrence of neurodegenerative or mental health disorders and 2) affect measures of br...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 721.1KB)
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- Publisher copy:
- 10.1371/journal.pone.0181392
Authors
Funding
+ HDH Wills 1965 Charitable Trust
More from this funder
Funding agency for:
Suri, S
Filippini, N
Mahmood, A
Grant:
1117747
1117747
1117747
+ National Institute for Health Researc
More from this funder
Funding agency for:
Heise, V
Sexton, C
Mackay, C
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS One Journal website
- Volume:
- 12
- Issue:
- 8
- Article number:
- e0181392
- Publication date:
- 2017-08-03
- Acceptance date:
- 2017-06-21
- DOI:
- ISSN:
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1932-6203
Item Description
- Pubs id:
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pubs:702864
- UUID:
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uuid:3759484b-b5e9-4a0f-af30-7712d13404ef
- Local pid:
- pubs:702864
- Source identifiers:
-
702864
- Deposit date:
- 2017-08-04
Terms of use
- Copyright holder:
- Heise et al
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Heise et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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