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Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery.

Abstract:

Apoptosis of neurons plays fundamental roles in brain development and disease. Although neurons share with other cell types components of the mitochondrial apoptotic machinery, how this machinery is specifically activated in neurons remains poorly understood. Remarkably, phosphorylation of the BH3-only protein BIMEL at Ser65 triggers apoptosis in neurons but suppresses cell death in non-neural cells. Here, we report that the prolyl isomerase Pin1 interacts with Ser65-phosphorylated BIMEL in n...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Neuron
Volume:
49
Issue:
5
Pages:
655-662
Publication date:
2006-03-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:3754c757-0607-46b2-a9df-6aaa06f3a354
Source identifiers:
248012
Local pid:
pubs:248012

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