Dosimetric explanations of fatigue in head and neck radiotherapy: an analysis from the PARSPORT Phase III trial.

Journal article

BACKGROUND: An unexpected finding from the phase III parotid sparing radiotherapy trial, PARSPORT (ISRCTN48243537, CRUK/03/005), was a statistically significant increase in acute fatigue for those patients who were treated with intensity-modulated radiotherapy (IMRT) compared to standard conventional radiotherapy (CRT). One possible explanation was the difference in dose to central nervous system (CNS) structures due to differing beam portals. Using data from the trial, a dosimetric analysis ...

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Authors: Gulliford, S; Miah, AB; Brennan, S; McQuaid, D; Clark, C

• Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
• Volume: 104
• Issue: 2
• Pages: 205-212
• Publication date: 2012-08-01
• DOI: 10.1016/j.radonc.2012.07.005
• EISSN: 1879-0887
• ISSN: 0167-8140
• Language: English
• Keywords: Neoplasm Staging; Fatigue; Head and Neck Neoplasms; Middle Aged; Dose-Response Relationship, Radiation; Neoplasm Invasiveness; Radiotherapy, Intensity-Modulated; Humans; Survival Rate; Radiometry; Male; Female; Incidence; Treatment Outcome; Central Nervous System; Radiotherapy Dosage; Follow-Up Studies; Risk Assessment; Aged; Parotid Neoplasms; Radiotherapy